منابع مشابه
Cell Cycle Regulation and Apoptosis1
Tissue homeostasis requires a balance between cell proliferation and death. Apoptosis and proliferation are linked by cell cycle regulators, and apoptotic stimuli affect both cell proliferation and death. Glucocorticoids induce G1 arrest and apoptosis in transformed lymphoid cells. Decreased expression of the cell cycle components c-myc and cyclin D3 is essential for glucocorticoid-induced grow...
متن کاملCytotoxic T Cells Overcome BCR-ABL-mediated Resistance to Apoptosis1
Chronic myeloid leukemia is a disease marked by expanded clonal hematopoiesis; it is incurable by chemotherapy or radiation but is cured in a majority of patients receiving bone marrow transplantation from nonidentical sibling donors, an outcome generally attributed to a T cellmediated graft-versus-leukemia effect. In this report, we examine the effect of the P210Bl R'ABI fusion protein of the ...
متن کاملTherapy of severe aplastic anemia with anti-human thymocyte globulin and androgens: the effect of HLA-haploidentical marrow infusion.
Fifty-four patients with severe aplastic anemia were treated with horse anti-human thymocyte globulin (ATG) and androgens. Thirty of these patients also received an infusion of HLA-haploidentical marrow cells. Only those patients having evidence of hematologic recovery within 3 mo after ATG therapy were considered responders to the immunosuppressive regimen. Of 53 patients evaluable for respons...
متن کاملAnalysis of thymocyte MHC specificity with thymocyte hybridomas
Medullary, peanut agglutinin-negative (PNA-), thymocytes were activated in vitro with either exogenous interleukin 1 (IL-1) or accessory cells. T cell blasts from these cultures were subsequently fused to BW5147 to generate thymocyte hybridomas. Fusion frequencies similar to those obtained with peripheral T lymphocytes were observed. A high frequency of these hybrids are triggered to produce IL...
متن کاملAndrogens and cardiovascular disease.
PURPOSE OF REVIEW There is increasing interest in age-related changes in sex hormone levels as a potentially treatable cause of ill-health in men. Relationships between androgens and cardiovascular disease will be discussed, with particular attention to more recently published research. RECENT FINDINGS In middle-aged and older men, lower testosterone levels are associated with insulin resista...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1998
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.139.2.5729